TAZOBACTAM

Tazobactam is a penicillin that is heavily modified and a sulfone. It inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. Simply put, it is an ingredient that can be added to certain antibiotics to make them less vulnerable to bacteria's antimicrobial resistance. Tazobactam is commonly used as in its sodium salt, tazobactam sodium form. Tazobactam is combined with the extended-spectrum β-lactam antibiotic piperacillin in the drug piperacillin/tazobactam, used in infections due to Pseudomonas aeruginosa. Tazobactam expands the spectrum of activity by making it effective against organisms that express β-lactamase and would normally degrade piperacillin. Piperacillin with tazobactam is penicillin antibiotic used to treat different infections caused by bacteria, like stomach, skin, pneumonia, and severe vaginal infections. Tazobactam is sold under the brand name Zerbaxa, Zosyn amongst others. Taiho Pharmaceutical Company filed some of the first patent related to making this medicine in 1982 and came into medical use in 1992. Since then the patents have expired, many other companies have made their formulations of this medicine.

Forms and dose:

Piperacillin is sold as Piperacillin/Tazobactam 4 g/0.5 g Powder for Solution for Infusion, where 1 vial has 4 g piperacillin as sodium salt and 0.5 g tazobactam as the sodium salt. The usual recommended adult dose is 4 g piperacillin / 0.5 g tazobactam administered every eight hours. While treating nosocomial pneumonia and bacterial infections in neutropenic patients, the usual recommended adult dose is 4 g piperacillin / 0.5 g tazobactam administered every six hours. For children under 2 years of age, the dose is 80 mg Piperacillin / 10 mg Tazobactam per kilo of body weight given every six hours for treating Neutropenic children with fever suspected to be due to bacterial infections. For treating Complicated intra-abdominal infections, the recommended dose is 100 mg Piperacillin / 12.5 mg Tazobactam per kilo of body weight given every eight hours.

The price of Tazobactam

In the USA, depending on the pharmacy and brands, for a supply of 10 powder for injection, the consumers have to pay between $69.30 and $138.60. the same supply of 10 powder for injection will cost around USD60 in India.

How does it work?

Tazobactam works by inhibiting the action of bacterial beta-lactamase producing organisms. These are normally resistant to beta-lactam antibiotics. Tazobactam augments the efficacy of antibiotic that would otherwise not be effective in treating certain infections.

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